WebIn obesity, high levels of saturated fatty acids (SFAs) contribute to adipose tissue inflammation and dysfunction. Obesity-induced macrophage infiltration leads to insulin resistance, but the adipocyte itself may play a role in generating the inflammatory milieu. Given our recent findings of the role of TLR4 in myeloid biasing in obesity, we ... WebApr 11, 2024 · Obesity, type 2 diabetes mellitus (T2DM), hyperlipidemia, ... TLR4, zonula occludens-1 (ZO-1), and occludin, semi-quantitative PCR was carried out on 20 ng of cDNA. The respective primers were used in 38 cycles of PCR amplification as follows: cycling temperatures: 30 s of denaturation at 94 °C, 30 s of annealing at 59 °C, and 1 min of ...
Association between the expression of TLR4, TLR2, and MyD88
WebMar 30, 2024 · The toll-like receptor 4 (TLR4) signaling pathway is acknowledged as one of the main triggers of the obesity-induced inflammatory response. The aim of the present review is to describe the role that is played by the TLR4 signaling pathway in the inflammatory response and its modulation by saturated and omega-3 polyunsaturated … WebAug 21, 2024 · The aim of this in vitro study was to examine the effect of raspberry polyphenolic extract on the immune-metabolic molecular mechanisms activated by obesity-related signals in hepatocytes (HB-8965®). Alterations in endosomal/lysosomal activity (neutral red uptake assay, NR), the expression of selected genes involved with lipid … gunther cw
Toll-like receptor status in obesity and metabolic …
WebApr 10, 2024 · 1.Introduction. As a chronic disease, obesity has become a major global public health problem. The prevalence of overweight or obesity is increasing worldwide every year, and growing with a pandemic trend [1], with serious negative impacts on human health and socio-economics.A 2024 report stated that “the prevalence of obesity has … WebA body of evidence suggests that TLR4 is an attractive candidate for linking innate immune responses to obesity and insulin resistance ( Fig. 26.2 ). First, TLR4 expression is … WebOct 16, 2012 · The objective of the present study was to elucidate the mechanism for a link between HFD and obesity, particularly the effects of endotoxin-induced inflammation via TLR4 signaling pathway in response to a HFD. Materials and Methods Reagents Antibodies were purchased from Cell signaling Technology (Danvers, MA). gunther cunningham nfl