WebOct 25, 2024 · Thrap3 colocalizes with R-loops, and Thrap3 depletion leads to R-loop accumulation. Thrap3 is an RNA-binding protein related to the DNA damage response … WebDec 4, 2024 · Thrap3 promotes osteogenesis by inhibiting the degradation of Runx2. Zhou L, Li H, Sun S, Zhang T, Yu Y, Xu L, Wang MZhou L, et al. FASEB J, 2024 Apr. PMID 35230719; Thrap3 promotes R-loop resolution via interaction with methylated DDX5. Kang HJ, Eom HJ, Kim H, Myung K, Kwon HM, Choi JHKang HJ, et al. Exp Mol Med, 2024 Oct. PMID 34697388
THRAP3 Gene - GeneCards TR150 Protein TR150 Antibody
WebTHRAP3 is a 955 amino acid novel nuclear receptor and a member of the Thyroid hormone receptor associated proteins with a LISH domain and no obvious known sequence motifs. THRAP3 is a 150 kDa subunit of the large multiprotein complex TRAP and is important in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar … WebTHRAP3 depletion increased basal and tumor necrosis factor α (TNFα)-induced lipolysis, proinflammatory gene expression, and phosphorylation of extracellular signal-regulated kinases (ERKs ... growing up right before our eyes
THRAP3 and BCLAF1 functionally compensate for each other. (A) THRAP3 …
WebOct 25, 2024 · Thrap3 is associated with XRN2 on R-loops, and XRN2 is a downstream target of Thrap3. a U2OS cell lysates were immunoprecipitated with normal IgG (IgG) or an anti-Thrap3 antibody (Thrap3). Precipitates and cell lysates were subjected to immunoblotting for Thrap3 and XRN2. b U2OS cells were transfected with RNaseH1 overexpression … WebSequence variants and/or copy number variants (deletions/duplications) within the THRAP3 gene will be detected with >99% sensitivity. Variants classified as unknown significance … WebTHRAP3. Addgene Alerts Receive email alerts when new plasmids with this gene become available. Log in to subscribe to Addgene Alerts. Description thyroid hormone receptor … growing up resources