Web21 mei 2024 · While it is unclear which specific c-Myc-regulated genes control ferroptosis, it is well established that c-Myc can bind to its canonical response element (E-boxes, CANNTG) present in the promoters of Tfr1 (transferrin receptor 1), ferritin (heavy and light chains), IRP2 (iron regulatory protein 2), and Nramp1 (natural resistance associated … Since ATF4 is critical for survival following MYC activation (Fig. 1c–e), we performed chromatin immunoprecipitation with sequencing (ChIP–seq) in DLD-1 MycER cells with or without MYC activation to map genes bound by ATF4 on a genome-wide scale. We identified 330 unique ATF4-binding sites that … Meer weergeven We previously reported that activation of MYC leads to phosphorylation of PERK and eIF2α11. To test whether MYC activation also … Meer weergeven Amino acid deficiency leads to accumulation of uncharged tRNAs, which in turn bind to GCN2, resulting in its autophosphorylation … Meer weergeven

Cancers Free Full-Text MYCN and Metabolic Reprogramming in ...

Web20 apr. 2024 · Notably, GCN2-eIF2α-ATF4 activation by MYC was recently described. By generating excess uncharged tRNAs, c-Myc induces an optimal expression of ATF4. Then, c-Myc and ATF4 cooperate to regulate a specific program of c-Myc target genes, mainly involved in amino acid and protein synthesis (Tameire et al, 2024). Web1 aug. 2024 · The ability of ATF4 to stabilize MYCN protein also suggests a molecular mechanism for the observation that ATF4 overexpression significantly enhanced the … barbara joel

ATF4 couples MYC-dependent translational activity to …

Web1 jul. 2024 · This study also found that when tumors in humans are driven by MYC, ATF4 and its protein partner 4E-BP are also overly expressed, which is further evidence that these findings may point to an approach that could work for humans. “This shows us the potential impacts of targeting ATF4 in MYC-dependent tumors, something we’re already studying. WebATF4 then activates PUMA and other genes (e.g., NOXA and TRB3) involved in the execution of cell death, sensitizing tumor cells to Myc-mediated apoptosis. Like Myc, ATF4 also plays a dual role in regulating cellular activities. ATF4’s typical role as a protective factor is well documented (. Ameri and Harris, 2008. Web（ATF4信号通路能够促进细胞收集必要的氨基酸来维持肿瘤生长和生存。 在细胞核内，ATF4 基因可通过 C/EBP-ATF 反应元件结合靶启动子，从而参与氨基酸合成、蛋白质正确折叠及降解、氧化还原平衡、自噬和凋亡等相关基因激活的转录调控过程。 ） 最后一步，手眼通天的A婆婆联系上一位工程师 （VEGF，血管内皮生长因子）， 计划和他一起促成 … barbara johnson obituary pa