WebGSH is a cofactor of conjugation and reduction reactions that are catalyzed by glutathione S-transferase enzymes expressed in the cytosol, microsomes, and mitochondria. However, it is capable of participating in non-enzymatic conjugation with some chemicals, as it is hypothesized to do to a significant extent with n-acetyl-p-benzoquinone imine ... WebJun 3, 2016 · ence of FosA-group glutathione-S-transferase ac tivity. However, PCR was negative for fosA3, which is the most commonly. report ed fosA gene in E. coli …

fosA FosA/FosA2 family fosfomycin resistance glutathione transferase []

WebJan 1, 2005 · Three similar but mechanistically distinct fosfomycin resistance proteins that catalyze the opening of the oxirane ring of the antibiotic are known. FosA is a Mn(II) and K + ‐dependent glutathione transferase. FosB is a Mg 2+ ‐dependent L‐cysteine thiol transferase. FosX is a Mn(II)‐dependent fosfomycin‐specific epoxide hydrolase. WebJun 3, 2016 · Plasmid-encoded glutathione-S-transferase (GST) FosA6 conferring high-level fosfomycin resistance was identified in a CTX-M-2-producing E. coli clinical strain at … henley house and land packages

Glutathione S-transferases--a review - PubMed

WebAbstract. The Glutathione S-transferases (GSTs) form a group of multi-gene isoenzymes involved in the cellular detoxification of both xenobiotic and endobiotic compounds. GSTs … WebSeveral significant advances in the understanding of the catalytic mechanisms, structures and evolution of glutathione transferases have occurred in the past year. These advances include new mechanistic information concerning the canonical soluble enzymes, the finding that the fosfomycin-specific enzyme, FosA, is a metalloglutathione ... WebFeb 1, 2005 · FosA is a glutathione transferase identified in various Gram-negative bacteria, which catalyzes the reaction between fosfomycin and glutathione (GSH), a low … henley hotel washington dc