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Erythronolide synthase

WebNov 24, 2010 · The collective polyketide synthase is referred to as deoxyerythronolide B synthase (DEBS) and is composed of the DEBS1, 2, and 3 enzymes (Figure 1 B). Furthermore, the system requires (2S)-methylmalonyl-CoA and propionyl-CoA substrates that may prompt separate metabolic engineering of the heterologous host to support … WebErythronolide synthase Erythronolide synthase. Dietmar Schomburg 2 & Dörte Stephan 2 Chapter; 11 ...

A polyketoacyl-CoA thiolase-dependent pathway for the ... - Nature

WebErythronolide synthase proteins 1, 2 and 3 from Saccharopolyspora erythraea which is involved in the biosynthesis of the polyketide antibiotic erythromicin. Each of these proteins contains two CP domains. Conidial green pigment synthase from Aspergillus nidulans. ACV synthase from various fungi. http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00825 hcs3302 https://tycorp.net

CDD Conserved Protein Domain Family: Docking - National Center …

WebErythronolide synthase, modules 5 and 6CALCIUM IONPENTAETHYLENE GLYCOL. ... 5D3K: Crystal structure of the thioesterase domain of deoxyerythronolide B synthase. PDB ID: 5D3K Download: MMDB ID: 134713: PDB Deposition Date: 2015/8/6: Updated in MMDB: 2015/12: Experimental Method: x-ray diffraction. Resolution: Source Organism: … WebMar 17, 2024 · Erythronolide B from Sugar-derived Homochiral Building Blocks. A strategy for an enantiospecific total synthesis of erythronolide B evolved from the recognition that the C2-4 and C10-12 segments are identically substituted but have different absolute stereochemistries. WebGene ID: 110857126, updated on 16-Feb-2024. Summary Other designations. reducing polyketide synthase swnK, Erythronolide synthase, modules 3 and 4, Erythronolide synthase, modules 3 and 4 golden acres carrington nd address

Synthesis of Erythronolide A

Category:3-oxo-arachidoyl-CoA synthase activity - Ontology Browser - Rat …

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Erythronolide synthase

Erythronolide synthase - Wikiwand

WebJun 22, 2024 · Interestingly, although BktB and PKS III orcinol synthase (ORS) are both capable of generating the same polyketide backbone, they share less than 10% protein sequence identity (Extended Data Fig. 3d). WebErythronolide synthase. NCBI. National Center for Biotechnology Information. Search. 1PZQ: Structure of fused docking domains from the erythromycin polyketide synthase …

Erythronolide synthase

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WebMar 1, 1994 · 6-deoxyerythronolide-B synthase; erythronolide condensing enzyme; malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing); ... Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel. Journal: Proc Natl Acad Sci U S A 98:14808-13 (2001) … WebThe antibiotic erythromycin is a complex polyketide of a 14-membered lactone called erythronolide B, which is connected to two deoxysugars called l-mycarose and d …

WebThis entry represents the the beta-ketoacyl synthase region from a number of polyketide synthases including erythronolide synthase and the lovastatin nonaketide chain … WebIn an uncompleted approach to erythronolide A, Sauve et al. 9 used Ireland's methodology and aimed for spiroketal template 12.1 (Scheme 12) in which the C1–C7 chain was …

WebEnzyme Commission Synonyms: erythronolide condensing enzyme, malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing), erythronolide synthase, malonyl-CoA:propanoyl-CoA malonyltransferase (cyclizing), deoxyerythronolide B synthase, 6-deoxyerythronolide B synthase, DEBS . ... WebJan 23, 2007 · Erythronolide synthase is composed of EryAI, EryAII and EryAIII multimodular (2 modules) polypeptides each coding for a functional synthase subunit which participates in 2 of the six FAS-like elongation steps required for formation of the polyketide. Module 1, 2, 3, 4, 5, and 6 participating in biosynthesis steps 1, 2, 3, 4, 5, and 6, …

WebMar 17, 2024 · A strategy for an enantiospecific total synthesis of erythronolide B evolved from the recognition that the C2-4 and C10-12 segments are identically substituted but …

WebOne of the BLASTp hits of an intestine-derived type I PKS contigs from the symbiotic microbiome of the mangrove shipworm Neoteredo reynei is an erythronolide synthase [53]. ... hcs-3402-usbWebSynthesis of Erythronolide A. Erythronolide A (4), with its array of ten stereogenic centers, is the parent of several classic antibiotics, including erythromycin.The key step in the … hcs 3370Websynthase, β-ketoacyl reductase, β-ketoacyl dehydratase enzyme-bound 6-deoxy-erythronolide seco acid (linear heptaketide) cyclization upon cleavage from polyketide … hcs 3404WebIn enzymology, an erythronolide synthase is an enzyme that catalyzes the chemical reaction golden acres chowchillaWeb8600 Rockville Pike, Bethesda, MD, 20894 USA. Contact. Policies. FOIA. HHS Vulnerability Disclosure. National Library of Medicine. National Institutes of Health. … hcs 3470 ohio stateWebProbable pks7,polyketide synthase, similar to many e.g. ERY2_SACER Q03132 erythronolide synthase, modules 3 and 4 (3567 aa), FASTA scores: E(): 0, (48.8% identity in 2131 aa overlap); also similar to Mycobacterium tuberculosis pks12. Contains PS00606 Beta-ketoacyl synthases active site, PS00012 Phosphopantetheine attachment site ... hcs 3400WebErythronolide synthase docking The N terminal docking domain found in modular polyketide synthase assumes an alpha-helical structure, wherein two alpha-helices are … golden acres christmas trees