Dlc1 rho gtpase activating protein
WebOct 3, 2013 · DLC1 encodes a RhoA GTPase-activating protein and tumor suppressor lost in cancer by genomic deletion or epigenetic silencing and loss of DLC1 gene … WebApr 11, 2024 · Metastatic prostate cancer (mPCa) has limited therapeutic options and a high mortality rate. The p21-activated kinase (PAK) family of proteins is important in cell survival, proliferation, and motility in physiology, and pathologies such as infectious, inflammatory, vascular, and neurological diseases as well as cancers. Group-I PAKs …
Dlc1 rho gtpase activating protein
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Web(Click on the icon in the table below to see search hit context) WebThe local regulation of Rho proteins is coordinated by the interaction with different guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) that turn on and off GTPase signaling to downstream effectors. GEFs and GAPs thus serve as critical signaling nodes that specify the amplitude and duration of a particular Rho ...
WebJul 1, 2008 · DLC1 is a Rho GAP. When DLC1 cDNA was first isolated, it was clear that the encoded 1091-amino-acid protein harbors a Rho GAP domain ... Thorgeirsson S.S., Popescu N.C. DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development. FEBS Lett. 2005; 579:1191–1196. [Google Scholar] WebNov 2, 2024 · Background: DLC1, a tumor suppressor gene that is downregulated in many cancer types by genetic and nongenetic mechanisms, encodes a protein whose RhoGAP and scaffolding activities contribute to its tumor suppressor functions. The role of the DLC1 START (StAR-related lipid transfer; DLC1-START) domain, other than its binding to …
WebSep 20, 2024 · We found that activated α 2-Macroglobulin (α 2 M*) a ligand of the CS-GRP78 receptor, induces formation of the AKT kinase (AKT)/DLC1 Rho-GTPase-activating protein (DLC1) complex and thereby increases Rho activation. Further, CS-GRP78 activated the transcriptional coactivators Yes-associated protein (YAP) and tafazzin … WebJul 19, 2016 · The RHO family of RAS-related GTPases in tumors may be activated by reduced levels of RHO GTPase accelerating proteins (GAPs). One common mechanism is decreased expression of one or more members of the Deleted in Liver Cancer (DLC) family of Rho-GAPs, which comprises three closely related genes (DLC1, DLC2, and DLC3) …
WebJan 1, 2009 · Deleted in liver cancer 1 (DLC1) is a Rho-GTPase-activating protein (GAP) that is downregulated in various tumor types. In vitro, DLC1 specifically inactivates the …
WebOct 30, 2024 · ARHGEF12 is important for platelet activation and thrombosis in mice, 38 but its role in erythropoiesis has not been defined. As a founding member of the Rho GTPase family, RhoA is involved in many important cellular functions, including gene transcription, survival, adhesion, and cytoskeleton reorganization. asti apukhtinaWebFeb 6, 2014 · DLC1-mediated increase in E-cadherin expression was not dependent on α-catenin, a DLC1-binding protein associated with E-cadherin, and/or cellular density. The increase of E-cadherin expression occurred at mRNA level and relied on DLC1 RhoGAP function, leading to suppression of high level of RhoA-GTP and RhoC-GTP activity in … larissa_1903WebThe Rho GTPase family accounts for as many as 20 members. Among them, the archetypes RhoA, Rac1, and Cdc42 have been the most well-characterized. Like all members of the small GTPases superfamily, Rho proteins act as molecular switches to control cellular processes by cycling between active, GTP-bound and inactive, GDP … larissa281WebA Rho GTPase-activating protein (RhoGAP), deleted in liver cancer 1 (DLC1), is known to function as a tumor suppressor in various cancer types; however, whether DLC1 is a tumor-suppressor gene or an oncogene in melanoma remains to be clarified. Here we revealed that high DLC1 expression was detected … astiaston vuokrausWebAug 15, 2024 · The DLC1 gene (deleted in liver cancer 1, STARD12, ARHGAP7) encodes a ubiquitously expressed Rho GTPase-activating protein that is a tumor suppressor and can regulate RhoA activity both in vitro ... laris hotel makassarWebDLC1 INFORMATION. Proteini. Full gene name according to HGNC. DLC1 Rho GTPase activating protein. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. DLC1 (ARHGAP7, DLC-1, HP, p122-RhoGAP, STARD12) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). larisa stout thdaWebJan 1, 2009 · Deleted in liver cancer 1 (DLC1) is a Rho-GTPase-activating protein (GAP) that is downregulated in various tumor types. In vitro, DLC1 specifically inactivates the small GTPases RhoA, RhoB and RhoC through its GAP domain and this appears to contribute to its tumor suppressor function in vivo. Molecular mechanisms that control DLC1 activity … larissa_319