Clinical implications of cancer self-seeding
WebFeb 1, 2008 · Request PDF On Feb 1, 2008, Larry Norton published Cancer Stem Cells, Self-Seeding, and Decremented Exponential Growth: Theoretical and Clinical Implications Find, read and cite all the ... WebApr 28, 2010 · The paper shows that circulating tumor cells can return to the primary tumor, a process termed tumor self-seeding or cross-seeding, and that this helps breeding tumor cells that give rise to aggressive metastatic variants. A viewpoint presented here addresses the implications of these studies for human cancer metastasis.
Clinical implications of cancer self-seeding
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WebHere, we show that the self-seeding model may answer many of the mysteries inherent to cancer metastasis. Indeed, reframing our understanding of metastasis within the self … WebApr 21, 2014 · E Comen, L Norton, J Massagué: Clinical implications of cancer self-seeding Nat Rev Clin Oncol 8: 369 – 377, 2011 Crossref, Medline, Google Scholar: 46. CA Klein: Parallel progression of primary tumours and metastases Nat Rev Cancer 9: 302 – 312, 2009 Crossref, Medline, Google Scholar: 47.
WebThe process by which circulating tumor cells return to the primary tumor is termed “tumor self-seeding”. 45 Indeed, CTCs circulate in the bloodstream in the whole body and show dissemination, seeding not only distant … WebSep 19, 2024 · Angiogenesis: overview. Angiogenesis is the formation of new blood vessels from pre-existing vessels. 1 – 4 It is a highly regulated process in which the interplay between pro-angiogenic and anti-angiogenic factors mediates the transition of vascular endothelium through different stages of vascular growth. Angiogenesis is divided into …
The conventional view of cancer is that cells from a primary tumour mutate toward metastatic potential as they grow and evolve, sending off metastatic cells as they … WebDec 24, 2009 · Self-seeding may provide harbor in a primary tumor for the expansion of cancer cell subpopulations that are primed for metastasis. As the shedding and …
Web1 Introduction. A functional linking between cancer and chronic inflammation has long been noted. In 1863, Virchow first described leukocyte infiltration within tumors and hypothesized that cancer originated from the sites of chronic inflammation (Korniluk et al., 2024).Tissue damages and the consequent chronic inflammation caused by certain types of irritants …
WebJun 1, 2011 · ... 13 The cancer self-seeding model is the theory that primary tumors act as a source of metastatic cells. 10 Circulating tumor cells derived from primary tumors … padre donizettiWebSelf-seeding of breast cancer, colon cancer, and melanoma tumors in mice is preferentially mediated by aggressive CTCs, including those with bone, lung, or brain-metastatic tropism. We find that the tumor-derived cytokines IL-6 and IL-8 act as CTC attractants whereas MMP1/collagenase-1 and the actin cytoskeleton component fascin-1 … インダイレクト エクセルWebIt is shown that the self-seeding model may answer many of the quandaries intrinsic to understanding how cancer spreads and ultimately kills, and redirecting research and treatment efforts within theSelf-seeded model may offer new possibilities for eradicating metastatic cancer. Despite significant progress in our understanding and treatment of … padre e figlio gmbhWebSelf-seeding refers to the proven ability of peripatetic cancer cells to migrate multidirectionally—seeding not only to regional and distant sites in the body, but also … インダイレクト関数WebThe clinical features of triple-negative breast cancer (TNBC) appear no expression of estrogen receptors (ER), HER2, and progesterone receptors (PR) on the surface of cancerous cells. The absence of characteristic biomarkers makes endocrine-related therapy not applicable for TNBC therapy. padre donizetti tambaúWebDec 24, 2009 · Self-Seeding of Cancer Cells May Play a Critical Role in Tumor Progression. Cancer progression is commonly thought of as a process involving the growth of a primary tumor followed by metastasis, … padre e figlia berlin hermsdorfWebJan 1, 2012 · The concept of tumors self-seeding by CTCs was first published in 2009 after validation of the theory in diverse experimental models including colon and breast … padre e figlia